Integrating high dose inhaled corticosteroids into oral corticosteroids stewardship
نویسندگان
چکیده
منابع مشابه
Absorption of high-dose inhaled corticosteroids.
The appropriate and safe use of inhaled corticosteroids (ICS) is an important issue in managing asthma, and we read with interest the article by Wales et al (June 1999).1 This is now the seventh report showing increased adrenal suppression with very high doses of fluticasone propionate (FP) compared to budesonide (BUD) in volunteers.2–7 However, normal subjects do not generally receive these do...
متن کاملAdrenal function and high dose inhaled corticosteroids for asthma.
OBJECTIVE To investigate effects on adrenal function of fluticasone, a recently released inhaled steroid preparation with lower systemic bioavailability than beclomethasone dipropionate. METHODS 34 children on high doses (400-909 micrograms/m2/d) of inhaled beclomethasone dipropionate or budesonide were recruited into a double blind, crossover study investigating the effects on adrenal functi...
متن کاملPurpura and dermal thinning associated with high dose inhaled corticosteroids.
OBJECTIVE To assess the effect of high dose inhaled corticosteroids on skin. DESIGN Cross sectional study of patients receiving treatment for chest diseases. SETTING Outpatient chest clinic in a teaching hospital. PATIENTS 68 Patients divided into four groups of similar age--namely, 15 receiving long term oral prednisolone, 21 receiving high dose inhaled corticosteroids, 15 receiving low ...
متن کاملInhaled Corticosteroids
Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress inflammation mainly by switching off multiple activated inflammatory genes through reversing histone acetylation via the recruitment of histone deacetylase 2 (HDAC2). Through suppression of airway inflammation ICS reduce airway hyperresponsiveness and control asthma symptoms. ICS are now first-line therapy...
متن کاملModerate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma.
BACKGROUND There is uncertainty as to the dose of inhaled corticosteroids (ICS) at which to start concomitant long acting beta agonist (LABA) treatment in patients with asthma not adequately controlled by ICS alone. METHODS A meta-analysis was carried out of randomised, double blind clinical trials that compared the efficacy of adding salmeterol to moderate doses of ICS (fluticasone propionat...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2020
ISSN: 0903-1936,1399-3003
DOI: 10.1183/13993003.02193-2019